A Machine-Learning Approach to Predicting Need for Hospitalization for Pediatric Asthma Exacerbation at the Time of Emergency Department Triage.

CONCLUSIONS: The gradient boosting machines model was the most successful at predicting need for hospitalization at the time of triage in pediatric patients presenting with asthma exacerbation. The addition of weather data significantly improved the performance of this model. This article is protected by copyright. All rights reserved. PMID: 30382605 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Acad Emerg Med Source Type: research

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Background Patients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown. Study setting A prospective observational study of adults with PCR-confirmed influenza in 11 UK hospitals, measuring nasal, nasopharyngeal and systemic immune mediators and whole-blood gene expression. Results Of 133 admissions, 40 (30%) had previous asthma; these were more often female (70% versus 38.7%, OR 3.69, 95% CI 1.67–8.18; p=0.0012), required less mechanical ventilation (15% versus 37.6%, Chi-squared 6.78; p=0.0338) and had shorter hospital stays (mean 8.3 versus 15.3 day...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Wheezing prevalence in the first year of life remains high. Despite the temporal assessment showing a decrease in the prevalence of recurrent wheezing, a significant increase in its morbidity was identified due to the higher number of hospitalizations. In addition, there were signs of improvement in the wheezing management of infants, reflected by an increase in the diagnosis of asthma and a greater indication of preventive treatments.
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
‚ÄčI recently met with a group from our children's hospital to standardize the hospital management of bronchiolitis according to the latest American Academy of Pediatrics guidelines. (Pediatrics 2014;134[5]:e1474; http://bit.ly/2QIGbMX.) Unfortunately, these guidelines seem to cause confusion for experienced and inexperienced emergency physicians alike.This confusion comes from the guidelines raising unaddressed issues and new questions, most importantly not tackling important aspects of frontline clinical practice. These guidelines were developed with the best evidence currently available, and their application mostly cau...
Source: M2E Too! Mellick's Multimedia EduBlog - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Conclusion: Despite efforts made, COPD is not fully treated as recommended by GOLD in 2017, most patients receive ICS without considering asthma associated diagnosis or exacerbation history
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
CONCLUSION: One-third of patients presenting to the ED with acute asthma were already receiving ICS/LABA agents; this treatment was independently associated with preventive measures. While ICS/LABA management improves control of chronic asthma, patients using these agents who develop acute asthma reflect higher severity and increased risk of future relapse. PMID: 30311821 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Abstract Once neglected in research and underappreciated in practice, there is renewed interest in bronchiectasis unrelated to cystic fibrosis. Bronchiectasis is a chronic lung disease characterised by chronic cough, sputum production and recurrent pulmonary exacerbations. It is diagnosed radiologically on high resolution computed tomography chest scan by bronchial dilatation (wider than the accompanying artery). The causes of bronchiectasis are diverse and include previous respiratory tract infections, chronic obstructive pulmonary disease, asthma, immunodeficiency and connective tissue diseases. A large proporti...
Source: Med J Aust - Category: General Medicine Authors: Tags: Med J Aust Source Type: research
AbstractPurposeTo determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia.MethodsSecondary analysis of a prospective cohort study of critically ill patients with confirmed influenza pneumonia admitted to 148 ICUs in Spain between June 2009 and April 2014. Patients who received corticosteroid treatment for causes other than viral pneumonia (e.g., refractory septic shock and asthma or chronic obstructive pulmonary disease [COPD] exacerbation) were excluded. Patients with corticosteroid therapy were compare...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
We report here the effect of CHF6297, a potent and selective inhaled p38MAPK inhibitor, in three murine models of steroid-resistant lung inflammation. In mice exposed to tobacco smoke (TS), CHF6297, administered intranasally (i.n.) b.i.d. for 4 days at 0.03 or 0.3mg/kg, dose-dependently inhibited the corticosteroid-resistant TS-induced neutrophil influx in bronchoalveolar lavage (BAL) reaching a % of inhibition of 29.7±15.3 (n.s.) and 62±8.4 (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway Pharmacology and Treatment Source Type: research
We report here the pharmacological characterization of the tool compound CHD39359, a PI3K selective inhibitor, and, in particular, its activity in a murine model of asthma exacerbation induced by IAV. CHD39359 inhibited PI3K enzyme and Akt phosphorylation in THP-1 monocytes with nanomolar potency (IC50=0.79nM and IC50=0.50nM, respectively) and showed>500-fold selectivity against PI3K, PI3Kβ and PI3Kα. CHD39359 inhibited mouse neutrophil chemotaxis with IC50=0.32nM and reduced oxidative burst with IC50=4.2nM in neutrophils obtained from COPD patients. In a corticosteroid-insensitive model of exacerbation induc...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway Cell Biology and Immunopathology Source Type: research
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