Mechanisms of Developmental Obesogen Exposure as Possible Drivers of Persistent Obesity Phenotypes in Adults

Background: Studies increasingly implicate chemical ‘obesogens’ as drivers of adiposity, hunger and reduced metabolism, and thereby contribute to the obesity epidemic. Dioctyl sodium sulfosuccinate (DOSS; CAS #577-11-7) is a widely used lipid emulsifier in processed foods and drinks, stool softeners and personal care products/cosmetics. To test a developmental origins of adult obesity model in a previous study, we administered DOSS to pregnant C57BL/6 mice in timing and dosage relevant to stool softener use during human pregnancy.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research