Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation

ConclusionsThe clusters during recovery from an exacerbation of asthma were distinguished by airflow obstruction and a neutrophilic, eosinophilic, or mixed inflammation. Eosinophilic inflammation was found in smoking and nonsmoking patients with asthma during an exacerbation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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Pediatric Allergy, Immunology, and Pulmonology,Volume 32, Issue 1, Page 31-34, March 2019.
Source: Pediatric, Allergy, Immunology, and Pulmonology - Category: Respiratory Medicine Authors: Source Type: research
AbstractKey content Antenatal corticosteroid use is strongly associated with reduced  neonatal mortality and morbidity arising from preterm delivery. Betamethasone and dexamethasone are the corticosteroids of choice to enhance fetal lung maturation in this situation. Maternal medical conditions such as autoimmune diseases, asthma and allergies may necessitate long‐term use of corticosteroids during pregnancy. The maternal, fetal and neonatal effects in pregnant women using chronic corticosteroids are reviewed. The question as to whether the standard course of antenatal corticosteroids is nec...
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: Review Source Type: research
Publication date: Available online 8 March 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Joe K. Gerald, Brian Hallmark, Dean Billheimer, Fernando D. Martinez, Lynn B. Gerald
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 8 March 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Tianshi David Wu, Emily P. Brigham, Corinne A. Keet, Todd T. Brown, Nadia N. Hansel, Meredith C. McCormackAbstractBackgroundMetabolic dysfunction may contribute to worsened asthma in obesity. The relationship between pre-diabetes and diabetes, metabolic conditions more common in obesity, and asthma outcomes is not well-characterized.ObjectiveWe sought to determine the association between pre-diabetes/diabetes and asthma exacerbations in an obese asthma cohort.MethodsA retrospective cohort of US obese...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsResults suggest lack of improvement in treatment and control since 2003 among children with asthma in the United States. There is significant room for improvement in asthma control and disease management among children.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Authors: Deepak L, Singh Rajput M, Sharma B Abstract Summary: Allergic bronchopulmonary mycosis (ABPM) is a clinical syndrome associated with immune sensitivity to various fungi that colonize the airways. Early diagnosis and treatment with systemic corticosteroids is the key in preventing the progression of the disease to irreversible lung fibrosis. Although Aspergillus has progressively gained recognition as a causative agent in past few decades, other fungi, that have been reported to cause ABPM, are not yet widely evaluated. We studied hundred and two patients with asthma for occurrence of ABPM. Patients were te...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
ConclusionChanges in persistent asthma care included replacement of ICS by FDCs, decreased use of LABAs as a monotherapy, and increased involvement of secondary care physicians. In parallel, despite low figures for hospital admissions and mortality, overall use of OCS and incidence of ER visits have increased over the last decade.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionWhile most PCPs and respiratory/allergy specialists can reach a working diagnosis of ACO, there remains uncertainty around which diagnostic features are most important and what constitutes optimal management. It is imperative that clinical studies including patients with ACO are initiated, allowing the generation of evidence ‐based management strategies.This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Purpose of review Asthma affects more than 25 million people worldwide and continues to grow in prevalence. According to a center for disease control and prevention (CDC) report, the total annual cost of asthma in the United States between 2008 and 2013, including medical care, absenteeism, and mortality, was $81.9 billion. Although the National Institute of Health guidelines recommend fixed inhaled corticosteroid (ICS) dosing, the 2008–2010 Medical Expenditure Panel Survey showed that asthma is still poorly controlled. Single inhaler maintenance and reliever therapy (SMART) offers a possible alternative management...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: PEDIATRIC ASTHMA AND DEVELOPMENT OF ATOPY: Edited by Leonard B. Bacharier and John Oppenheimer Source Type: research
Purpose of review Children with poor asthma control despite maximal maintenance therapy have problematic severe asthma (PSA). A step-wise approach including objective adherence monitoring and a detailed multidisciplinary team assessment to identify modifiable factors contributing to poor control is needed prior to considering therapy escalation. Pathophysiological phenotyping in those with true severe therapy-resistant asthma (STRA) and the current array of add-on therapies will be discussed. Recent findings Adherence monitoring using electronic devices has shown that only 20–30% of children with PSA have STRA a...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: PEDIATRIC ASTHMA AND DEVELOPMENT OF ATOPY: Edited by Leonard B. Bacharier and John Oppenheimer Source Type: research
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