Drug eruption by antihistamine mistaken for chronic urticaria in a child.

Drug eruption by antihistamine mistaken for chronic urticaria in a child. Korean J Pediatr. 2018 Oct 30;: Authors: Lee GM, Chu SY, Kang SY, Kim HB, Park JS, Kim JK Abstract Although rare, antihistamines can casue adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax® (hydroxyzine) or leptizine® (levocetirizine), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and eruptions. Levocetirizine induced wheals in the skin prick test and a rash in the oral drug provocation test. In contrast, ketotifen induced no reaction in the skin prick test but showed a positive reaction in the oral provocation test. Our case report highlights that children can experience the same types of adverse reactions as seen in adults, and cross-reactivity between various antihistamines can occur. PMID: 30376706 [PubMed - as supplied by publisher]
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research