Editorial for adult CSF total protein: Higher upper reference limits should be considered worldwide. A web-based survey

The cerebrospinal fluid total protein level is commonly used as an indicator or marker of several diseases of the peripheral - (PNS) and central nervous system (CNS). Worldwide most laboratories use the upper reference limit of 0.45  g/L for CSF protein. Based on own investigations and a global survey the authors of this paper research the worldwide upper reference limits [1]. The overarching question was, if this upper limit was a fixed level, or subject to age related changes. This investigation refers to CSF usually obtain ed by lumbar puncture and does not consider the ventricular CSF [2], nor children [3].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Editorial Source Type: research