Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts.

Escherichia coli is the leading cause of bacteraemia. In an era of emerging multi-drug-resistant strains, development of effective preventative strategies will be informed by knowledge of strain diversity associated with specific infective syndromes/patient groups. We hypothesised that the number of virulence factor (VF) genes amongst bacteraemia isolates from neutropaenic patients would be lower than isolates from immunocompetent patients.

Source: Journal of Infection - November 1, 2018 Category: Infectious Diseases Authors: Dr Adam P. Dale, Dr Anish K. Pandey, Dr Richard J. Hesp, Dr Konstantinos Belogiannis, Dr Jay R. Laver, Dr Clifford C. Shone, Professor Robert C. Read Source Type: research