The predictive value of morphological findings in early diagnosis of acute myeloid leukemia with recurrent cytogenetic abnormalities

Since the introduction of the French-American-British (FAB) morphological system, acute leukemia classifications were traditionally based on quantitative and qualitative evaluation of blast populations in bone marrow [1]. Although revolutionary at that time, particularly in the identification of acute promyelocytic leukemia (APL), the FAB morphological system had poor reproducibility and prognostic value [2,3]. Further developments in the fields of cell immunophenotyping by flow cytometry, cytogenetic and molecular genetic analysis provided new insights into leukemia biology, opening a new era of the integrated diagnostic approach, based on combined morphological, imunophenotypical and cytogenetical analyses [4].

Source: Leukemia Research - November 1, 2018 Category: Hematology Authors: Ljubomir Jakovic, Andrija Bogdanovic, Vesna Djordjevic, Marija Dencic-Fekete, Nada Kraguljac-Kurtovic, Vesna Knezevic, Natasa Tosic, Sonja Pavlovic, Tatjana Terzic Tags: Research paper Source Type: research