Exposure of pregnant mice to triclosan causes hyperphagic obesity of offspring via the hypermethylation of proopiomelanocortin promoter.
This study demonstrates that TCS exposure during early/mid-gestation through the hypermethylation of the POMC promoter reduces the expression of anorexigenic neuropeptides to cause the postnatal hyperphagic obesity, leading to metabolic syndrome in adulthood.
PMID: 30377736 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - Category: Toxicology Authors: Hua X, Xiong JW, Zhang YJ, Cao XY, Sun P, Wu J, Chen L Tags: Arch Toxicol Source Type: research
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