10th Patient Dies in Viral Outbreak at New Jersey Pediatric Facility

TRENTON, N.J. (AP) — Health officials say a 10th patient has died from an infection at a pediatric care facility in New Jersey as a different strain of the virus has been found at another facility in the state. The state health department on Wednesday confirmed the "medically fragile child" at the Wanaque Center for Nursing and Rehabilitation had the adenovirus infection. The department says 27 cases have been associated with the respiratory virus at the center. The affected children had severely compromised immune systems. One death was a young adult. Meanwhile, the state says there are four confirmed adenovirus cases among pediatric patients at Voorhees Pediatric Facility, near Philadelphia. Preliminary tests have ruled out the strain linked to the 10 deaths at the Wanaque facility. All contents © copyright 2018 Associated Press. All rights reserved.
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Tags: Patient Care News Source Type: news

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PMID: 30932693 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Purpose of review Transmission of acute respiratory tract viral infections in healthcare environments is a major problem worldwide. We review recent literature of viruses imported to hospitals from the local community and from abroad, their modes of transmission and measures required to reduce and contain them. Recent findings Common causes of outbreaks include influenza viruses, respiratory syncytial virus, adenovirus, and coronaviruses. Major lethal outbreaks of viral respiratory infections in hospitals have been caused by coronaviruses imported from abroad by travelers. Summary Although viruses circulating in th...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
In this study, the diagnostic accuracy of InGenius Gastrointestinal Viral (GV) Elite Panel, a newly developed one-step multiplex real-time RT-PCR assay simultaneously detecting rotavirus, adenovirus and astrovirus, was evaluated retrospectively analyzing an archival collection of 128 stool samples of children hospitalized with acute gastroenteritis. The overall sensitivity and specificity for the GV assay was 100% and 96.2% for rotavirus, 96.9% and 100% for astrovirus, 100% and 100% for adenovirus, respectively. The InGenius GV assay showed a high concordance with the reference methods and was able to detect all tested gen...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
A viral outbreak killed 11 children at a New Jersey health center last year due to a lack of administrative oversight, slow responses from medical staff and a flawed infection-control plan, according to a federal investigation. Wanaque Center for Nursing and Rehabilitation in Haskell, N.J. is strongly contesting investigators’ findings. The 114-page report, which was compiled by the New York regional office of the Centers for Medicare and Medicaid Services (CMS) and reviewed by TIME, says the pediatric medical director at the Wanaque Center “didn’t understand what medical director meant” when he ass...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Infectious Disease New Jersey onetime Source Type: news
The objectives of this study were to compare the historic African MR766 ZIKV strain with two epidemic Brazilian strains (BR15 and ICD) for their abilities to initiate viral infection and to confer neurocytopathic effects in the human brain’s SNB-19 glial cells, and further to determine which part of the ZIKV structural proteins are responsible for the observed differences. Our results show that the historic African (MR766) and epidemic Brazilian (BR15 and ICD) ZIKV strains are different in viral attachment to host neuronal cells, viral permissiveness and replication, as well as in the induction of cytopathic effe...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, we used crAssphage, a recently discovered human-specific gut-associated bacteriophage, for the surveillance of wastewater-derived viral contamination. Untreated and treated wastewater, surface water, sediment and mussel samples were collected monthly over 1 year from the Conwy River and estuary (UK) and were analyzed for crAssphage marker by quantitative PCR. This is the first long-term catchment-to-coast scale study of environmental crAssphage concentrations. CrAssphage was detected in all sample types and showed no distinct seasonal pattern. CrAssphage concentrations were 2  × 105&ndash...
Source: Food and Environmental Virology - Category: Virology Source Type: research
ang Donald Seto Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these “old” HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian popul...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
Conclusion: The XCP rate and the percentage of specimens positive for Cp increased in early 2014, peaking in May. Only 12% of trainees with laboratory-confirmed Cp were febrile. Historically, acute respiratory disease surveillance at military training centers focused on febrile diseases, particularly those caused by adenoviruses. With introduction of an adenovirus vaccine in late 2011, respiratory disease rates dropped with only sporadic occurrences of adenovirus-associated disease. In 2012, the San Diego surveillance program began providing data on multiple respiratory disease agents, in addition to adenoviruses and influ...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
AbstractHuman adenovirus (HAdV) is a common pathogen causing respiratory infections with outbreaks reported in the military and community. However, little information is available on the shedding kinetics. We performed a prospective study of immunocompetent adults confirmed with HAdV respiratory infection by multiplex real-time PCR during an outbreak of HAdV-55. Consecutive respiratory specimens of sputum or nasopharyngeal swab were collected from each patient every 2  days. Viral load was measured by real-time quantitative PCR. Of 32 enrolled patients, 27 (84.4%) had pneumonia. Five patients (15.6%) received cidofovi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Adriana E Kajon, Daryl M Lamson, Kirsten St. GeorgeHuman adenoviruses (HAdVs) are prevalent causes of acute respiratory disease (ARD) in military and civilian communities. Over the last 20 years, collaborative efforts between US public health, military and academic laboratories have gathered comprehensive data documenting the emergence and re-emergence of specific HAdV types in association with outbreaks and unrelated cases of ARD, which have attracted national attention. New or reemerging HAdVs have included genomic variants of HAdV-B1...
Source: Current Opinion in Virology - Category: Virology Source Type: research
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