Longitudinal Characterization of mGluR5 Using 11C-ABP688 PET Imaging in the Q175 Mouse Model of Huntington Disease

Conclusion: In vivo imaging of mGluR5 using 11C-ABP688 PET/CT revealed a marked reduction in ligand binding in the striatum and cortex of heterozygous mice, compared with WT mice, as well as a temporal decline. This study suggests that 11C-ABP688 PET imaging is a potential biomarker to monitor the progression of, and therapeutic strategies for, Huntington disease.

Source: Journal of Nuclear Medicine - November 1, 2018 Category: Nuclear Medicine Authors: Bertoglio, D., Kosten, L., Verhaeghe, J., Thomae, D., Wyffels, L., Stroobants, S., Wityak, J., Dominguez, C., Mrzljak, L., Staelens, S. Tags: Basic Source Type: research