Experts recommend tumor removal as first-line treatment for acromegaly

(The Endocrine Society) The Endocrine Society today issued a Clinical Practice Guideline for the diagnosis and treatment of acromegaly, a rare condition caused by excess growth hormone in the blood.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Skeleton of Charles Byrne, who had gigantism, could now be buried at sea in accordance with his final wishesThe “Irish giant”, a centrepiece of the Hunterian anatomical museum in London, could be released to allow the remains to be given a respectful burial after more than two centuries on display.The skeleton is that ofCharles Byrne, an 18th-century man who had a genetic form of gigantism that caused him to grow to more than 2.31 metres (7ft 7in) tall.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Museums Science Biology Genetics Source Type: news
Chloe Powell, a 26-year-old midwife from Bristol, developed acromegaly because of a benign brain tumour, which made her hands and feet grow uncontrollably, and her facial features swell up.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Source: JDDG - Category: Dermatology Authors: Source Type: research
Authors: Mercado M, Ramírez-Rentería C Abstract Diabetes is recognized as one of the most common acromegaly co-morbidities with a prevalence ranging 20-53%, while over one-third of these patients have an altered lipid profile. In fact, as in the non-acromegalic population, carbohydrate and lipid metabolism abnormalities are closely linked. Long term exposure to an excess of growth hormone (GH) and Insulin-like growth factor-1 concentrations results in insulin resistance and an increased hepatic glucose production. The lipolytic effect of GH results in the mobilization of free fatty acids that further ...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
Source: Endocrine - Category: Endocrinology Source Type: research
The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and acromegaly. Thirty-one patients with acromegaly, 28 patients with prolactinoma, and 33 healthy individuals were included in the study. Serum concentrations of RANKL, OPG, bone alkaline phosphatase (bone ALP), osteocalcin (OC), C-terminal telopeptide of type 1 collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP)...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
J. A. Goldbogen and P. T. Madsen The extant diversity and rich fossil record of cetaceans provides an extraordinary evolutionary context for investigating the relationship between form, function and ecology. The transition from terrestrial to marine ecosystems is associated with a complex suite of morphological and physiological adaptations that were required for a fully aquatic mammalian life history. Two specific functional innovations that characterize the two great clades of cetaceans, echolocation in toothed whales (Odontoceti) and filter feeding in baleen whales (Mysticeti), provide a powerful comparative framework ...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: COMMENTARY Source Type: research
Conclusions Excessive growth hormone secretion persisting after pituitary surgery and irradiation can be controlled in a convenient way for the patient with acromegaly by combining monthly lanreotide and weekly pegvisomant injections, if monotherapy with a somatostatin analog fails. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes Reports - Category: Endocrinology Authors: Tags: Case Report Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0629-9223 Purpose Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. Methods We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. On the basis of availability of pathological specimen of thyroid tissues,...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Condition:   Acromegaly Interventions:   Drug: IONIS-GHR-LRx;   Drug: Placebo Sponsor:   Ionis Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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