Elevated expression of Twinfilin-1 is correlated with inferior prognosis of lung adenocarcinoma

Publication date: Available online 31 October 2018Source: Life SciencesAuthor(s): Zhang Kaishang, Pan Xue, Zheng Shaozhong, Fan Yingying, Zhang Yan, Sun Chanjun, Li Zhenzhen, Li XiangnanAbstractAimTwinfilin-1 (TWF1) has been implicated in cell motility, invasion and migration. However, its exact role in lung cancer progression is still unclear. In the present study, we explored clinical and prognostic relevance of Twinfilin-1 (TWF1) levels for non-small cell lung carcinoma (NSCLC).Main methodsThe Cancer Genome Atlas (TCGA) dataset was analyzed for possible association between TWF1 expressions in NSCLC tissues and patient prognosis. The meta-analysis data was validated in our clinical study through techniques of immunoblotting, expression analysis and immunohistochemistry.Key findingsLung adenocarcinoma (LUAD) as well as lung squamous cell carcinoma (LUSC) showed significantly elevated expression of TWF1 compared to normal lung tissues. Univariate Cox regression analysis showed high expression of TWF1 to be independent prognostic indicator involved in overall survival (hazard ratio: 1.636; 95% CI: 1.223–2.189) and recurrence-free survival (hazard ratio: 1.551; 95% CI: 1.158–2.077) in LUAD, but not in LUSC. Similar trend was found in our clinical study. LUAD tissues reflected TWF1 overexpression to be positively correlated with grade of tumor, size and lymph node metastasis. Enhanced TWF1 expression was identified to be an independent predictor for the disadvantageous progn...
Source: Life Sciences - Category: Biology Source Type: research