Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin

ConclusionsThe present study showed that CYP-induced cystitis in mice is a model of visceral hyperalgesia affecting detrusor contractions, not urethral activations. The technique of using EUS  EMG to evaluate the drug effects on urethral activities is novel and useful for future investigations. Gabapentin can be as a potential treatment for detrusor overactivity and PBS/IC.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research