Fatal measles case highlights importance of herd immunity in protecting the vulnerable

(Infectious Diseases Society of America) Last year, a 26-year-old man receiving treatment for leukemia went to a Swiss hospital's emergency room with a fever, a sore throat, and a cough, and was admitted. His condition worsened, and 17 days later, he died from severe complications of measles. The man's weakened immune system was unable to fight off the disease, even though he was vaccinated against measles as a child.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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The cover image is based on the Clinical MessageChronic lymphocytic leukemia with progressive anemia secondary to development of composite lymphoma by Habib Moshref Razavi, James England, Jeffrey Craig et al.,https://doi.org/10.1002/ccr3.2656.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: FRONT COVER Source Type: research
Authors: Zhang N, Wang H, Yang J PMID: 32100488 [PubMed - in process]
Source: Journal of Gynecologic Oncology - Category: OBGYN Tags: J Gynecol Oncol Source Type: research
Publication date: Available online 26 February 2020Source: International Journal of PharmaceuticsAuthor(s): Luhui Fan, Cong Liu, Anzhi Hu, Jing Liang, Fanzhu Li, Yang Xiong, Chao-Feng Mu
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: May 2020Source: Biomedicine &Pharmacotherapy, Volume 125Author(s): Wen Lei, Shibing Wang, Nengwen Xu, Yu Chen, Gongqiang Wu, Aibin Zhang, Xiaomin Chen, Yin Tong, Wenbin Qian
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In the present study, we investigated the expression of hKLF3 in acute leukemia patients by both Sanger sequencing and RT ‐qPCR. ROC analyses indicated excellent efficacy of hKLF3 expression in PB samples for the diagnosis of AML. In addition, a significantly converse correlation between inhibition of hKLF3 expression in peripheral blood and increased leukemic burden was observed. AbstractBackgroundUniversal gene targets are in persistent demand by real ‐time quantitative polymerase chain reaction (RT‐qPCR)‐based methods in acute leukemia (AL) diagnosis and monitoring. Human Krüppel‐like factor 3 (hKLF3), a ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
In this study, we used bioinformatic analysis methods to integrate the candidate genes and pathways participating in GC resistance in ALL and subsequently verified the bioinformatics findings with in vitro cell experiments. Ninety ‐nine significant common differentially expressed genes (DEGs) associated with GC resistance were determined by integrating two gene profile datasets, including GC‐sensitive and ‐resistant samples. Using Kyoto Encyclopedia of Genes and Genomes (KEGG) and REACTOME pathways analysis, the signali ng pathways in which DEGs were significantly enriched were clustered. The GC resistance‐related ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Purpose of review The aim of this article is to provide an update on occupational aspects of irritable larynx syndrome (ILS). Recent findings It is being increasingly recognized that ILS is common amongst certain occupations. This is particularly true of occupations that require frequent voice use such as teachers; where there is exposure to workplace irritants such as World Trade Center responders; or mechanical factors that cause laryngeal dysfunction such as elite athletes. Work associated ILS impacts on quality of life but responds to speech and language therapy focusing on education, vocal hygiene, and laryngeal ...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: OCCUPATIONAL DISEASE: Edited by Susan M. Tarlo and Piero Maestrelli Source Type: research
A universal strategy is proposed for the fabrication of an antibody ‐free hydrogel that has a synergistic effect by featuring microinterfaces obtained by cell imprinting and molecular recognition conferred by boronate affinity. This 3‐AAPBA‐assisted cell‐imprinted hydrogel not only captures target tumor cells from blood with high efficiency and selectivity b ut also releases undamaged cells. AbstractThe selective and highly efficient capture of circulating tumor cells (CTCs) from blood and their subsequent release without damage are very important for the early diagnosis of tumors and for understanding the mechanis...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research
Conclusions: In this observational, routine-practice study, patients in all groups displayed a benefit from abobotulinumtoxinA treatment, supporting the effectiveness of treatment for patients at various disease stages. Although the data revealed some trends in favor of early vs. late treatment, we did not find strong evidence for a significant benefit of early vs. late start of treatment in terms of reduction in MAS scores.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 26 February 2020Source: Antiviral ResearchAuthor(s): Hyeon Cheol Kim, Dong Sun Oh, Jang Hyun Park, Hyun-Jin Kim, Yong Bok Seo, Hye Jee Yoo, Hye Seon Jang, Jua Shin, Chae Won Kim, Myeong Seung Kwon, Hyun-Tak Jin, Sung Ki Lee, Ji Eun Oh, Heung Kyu Lee
Source: Antiviral Therapy - Category: Virology Source Type: research
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