Fatal measles case highlights importance of herd immunity in protecting the vulnerable

(Infectious Diseases Society of America) Last year, a 26-year-old man receiving treatment for leukemia went to a Swiss hospital's emergency room with a fever, a sore throat, and a cough, and was admitted. His condition worsened, and 17 days later, he died from severe complications of measles. The man's weakened immune system was unable to fight off the disease, even though he was vaccinated against measles as a child.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Wnt/β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia. Oncol Rep. 2018 Dec 04;: Authors: Fu J, Si L, Zhuang Y, Zhang A, Sun N, Li D, Hao B, Ju X Abstract Although ~80% of newly diagnosed pediatric patients with acute lymphoblastic leukemia (ALL) become disease‑free following appropriate treatment, relapses frequently occur, with dismal prognosis. Therefore, it is urgent to develop novel therapeutic modalities. Resistance to chemotherapy is a major obstacle for the treatment of relapsed ALL. It has been indicated that Wnt pathway is potentially associa...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Potential efficacy and prognosis of silencing the CRLF2‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia. Oncol Rep. 2018 Dec 07;: Authors: Jiang M, Zou X, Lu L Abstract Acute B‑cell lymphoblastic leukemia (B‑ALL) is a common type of blood cancer, which is associated with aberrant gene expression. Cytokine receptor‑like factor 2 (CRLF2) serves a crucial role in the growth and allergic and inflammatory responses of dendritic cells and T cells. The purpose of the present study was to investigate the potential therapeutic and prognostic effect of silencing the CRLF2‑m...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Clinicians now have a new treatment to offer elderly patients with newly diagnosed acute myeloid leukemia who have comorbidities that preclude the use of intensive chemotherapy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
The US Food and Drug Administration recently approved a new agent for  treatment of adult patients with relapsed or refractory acute myeloid leukemia.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
This study analyzes quality traits of longissimus lumborum and gluteus medius in surgically castrated (SC) males, inmunocastrated (IC) males and IC female Iberian pigs reared in intensive conditions (n = 18/sex). Vaccination with Improvac® was applied at 18 and 26 weeks of age and slaughtering at 31 weeks. At such conditions, notable sex differences were found. Both muscles of IC males were less red (P 
Source: Meat Science - Category: Food Science Source Type: research
Publication date: Available online 12 December 2018Source: Parasitology InternationalAuthor(s): Eva-Maria Zottler, Monika Bieri, Walter Basso, Manuela SchnyderAbstractEndoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples...
Source: Parasitology International - Category: Parasitology Source Type: research
This study evaluated different gilt vaccination protocols against Mycoplasma (M.) hyopneumoniae at acclimation and their effect on the genetic diversity. A total of 180 M. hyopneumoniae naïve gilts were selected 1 week post-entry (wpe) at the acclimation barn in a clinically affected M. hyopneumoniae farm. Gilts were distributed according to the M. hyopneumoniae antibodies levels into three different vaccination schedules: A) four doses of a M. hyopneumoniae commercial vaccine at 2, 4, 6 and 8 wpe; B) two vaccine doses at 2 and 6 wpe and PBS at 4 and 8 wpe; and C) four PBS doses at the same wpe. Detection of M. hyopne...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, we used whole-genome sequencing with PacBio and Illumina platforms to analyse the molecular features of the multidrug-resistant enterotoxigenic Escherichia coli (ETEC) strain 14OD0056 and the multidrug-resistant hybrid Shiga toxin-producing/enterotoxigenic Escherichia coli (STEC/ETEC) strain 15OD0495 isolated from diarrheic pigs in Switzerland.Strain 14OD0056 possessed three virulence plasmids similar to others previously found in ETEC strains, while 15OD0495 harboured a 119-kb multivirulence IncFII/IncX1 hybrid STEC/ETEC plasmid (p15ODTXV) that co-carried virulence genes of both ETEC and STEC pathotypes, co...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Publication date: March 2019Source: Fish &Shellfish Immunology, Volume 86Author(s): Saekil Yun, Jin Woo Jun, Sib Sankar Giri, Hyoun Joong Kim, Cheng Chi, Sang Geun Kim, Sang Wha Kim, Jung Woo Kang, Se Jin Han, Jun Kwon, Woo Taek Oh, Se Chang ParkAbstractOver the last 50 years, various approaches have been established for the development of antigens for immunostimulation. We used phage lysate (PL), composed of inactivated antigens by the lytic bacteriophage pAh 6-c for Aeromonas hydrophila JUNAH strain to develop a vaccine for the prevention of A. hydrophila infection in Cyprinus carpio (common carp). We also assessed t...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 13 December 2018Source: Advances in Biological RegulationAuthor(s): Yuri Pekarsky, Carlo M. CroceAbstractBy using chronic lymphocytic leukemia as target for discovery in cancer pathogenesis we discovered that the great majority of CLLs (75–85%) carry a deletion of miR-15a and miR-16-1 at 13q14. We also discovered that miR-15/16 are negative regulators of the BCL2 oncogene. Thus the loss of the two negative regulators causes BCL2 overexpression and leukemia. A corollary of this is that CLL is very sensitive to the anti BCL2 drug venetoclax that can induce complete remission in CLL ...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
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