Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man.

Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man. Curr Vasc Pharmacol. 2018 Oct 30;: Authors: Wiggenhauser LM, Kroll J Abstract Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of a negative prognosis in diabetes-induced micro- and macrovascular complications. Insight into the capability of zebrafish to model metabolic disease like obesity and type II diabetes has increased and new evidence on the induction of vascular pathologies in zebrafish through metabolic disease is available. Here, we raise the question, if zebrafish can be utilized to study the initial impairments of vascular complications in metabolic disorders. In this review, we focus on the advances made to develop models of obesity and type II diabetes in zebrafish, discuss the key points and characteristics of these models, while highlighting the available information linked to the development of endothelial dysfunction in zebrafish and man. We show that larval and adult zebrafish develop metabolic dysregulation in settings of obesity and diabetes, exhibiting pathophysiological mechanisms, which mimic the human condition. The most important genes related to endothelial dysfunction are present in zebrafish and further display similar functions as in mammals. Several suggested contributors to endothelial dysfunction fo...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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Publication date: June 2019Source: Global Heart, Volume 14, Issue 2Author(s): Alemayehu Amberbir, Sabrina H. Lin, Joshua Berman, Adamson Muula, Darren Jacoby, Emily Wroe, Cecilia Maliwichi-Nyirenda, Victor Mwapasa, Amelia Crampin, Martha Makwero, Emmanuel Singogo, Sam Phiri, Stephen Gordon, Sheldon W. Tobe, Jones Masiye, Brad Newsome, Mina Hosseinipour, Moffat J. Nyirenda, Joep J. van OosterhoutAbstractRecent studies have found an increasing burden of noncommunicable diseases in sub-Saharan Africa. A compressive search of PubMed, Medline, EMBASE, and the World Health Organization Global Health Library databases was underta...
Source: Global Heart - Category: Cardiology Source Type: research
The human microbiome is closely related to human health status. Disruption of the symbiotic balance of the human microbiome is commonly found in systematic diseases such as diabetes, obesity, and chronic gastric diseases. The human microbiome confers benefits or disease susceptibility to the human body through multiple pathways, associated with approximately 20% of malignancies. The incidence and mortality of lung cancer (LC) in men in China are the highest among all malignancies, which is a serious threat to human health. Emerging evidence has suggested that the human microbiota may be closely related to lung cancer at mu...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conditions:   Prediabetic State;   Obesity;   Gestational Diabetes Interventions:   Behavioral: Presessions;   Behavioral: National Diabetes Prevention Program Sponsors:   Denver Health and Hospital Authority;   University of Colorado, Denver Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
 In this episode of Inside Schizophrenia, our hosts tackle the topic of early onset – or childhood – schizophrenia. Host Rachel Star discusses her personal experiences with schizophrenia symptoms as an adolescent and Dr. Joseph Gonzalez-Heydrich from Harvard Medical School discusses some of the latest research. Listen in now! About Our Guest Joseph Gonzalez-Heydrich, MD is Director of the Developmental Neuropsychiatry Clinic at Boston Children’s Hospital and an Associate Professor of Psychiatry at the Harvard Medical School. He did his undergraduate and medical school at Johns Hopkins, his residency t...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders Inside Schizophrenia Psychiatry Source Type: blogs
Conclusion: The presence of the PNPLA3 G allele is associated with a risk of NAFLD. Our study shows that subjects with variant PNPLA3 are not only at increased risk for the development and progression of NAFLD, but also have increased insulin resistance. PMID: 31304703 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent sources of inflammation inhabit other metabolic regulatory tissues, including liver and gut, and recirculate to promote systemic inflammation and thus obesity comorbidities. Tissue-associated immune cells, especially T cell subpopulations, have become a hotspot of inquiry based on their contributions to obesi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractBackgroundIdentifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes.PurposeWe assessed conversion rates to diabetes 5  years after three types of metabolic surgery and examined predictors of diabetes development.MethodsWe accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100 –125 mg/dL (5.6–6.9 mmol/L) or HbA1c 5.7–6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002–2011.ResultsOf 1,756 individuals with...
Source: Obesity Surgery - Category: Surgery Source Type: research
We present an explanatory hypothesis with a model that integrate central and peripheral dopaminergic circuits in the relationship between neuroimmune and metabolic systems in obesity-associated inflammation. A perspective on the potential role of dopaminergic drugs in the context of obesity will be given.Graphical AbstractGraphical representation of central and peripheral dopaminergic pathways in obesity-associated inflammation
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Barton BB, Zagler A, Engl K, Rihs L, Musil R Abstract The information on prevalence of obesity, diabetes, metabolic syndrome (MetS) and cardiovascular risk (CVR) and on sociodemographic variables available in patients with psychiatric diseases about to be treated with weight gain-associated medication (e.g., clozapine, mirtazapine, quetiapine) is limited. In a naturalistic study, psychiatric inpatients (age: 18-75) of all F diagnoses according to ICD-10, who were about to be treated with weight gain-associated medication, were included. Demographic variables were assessed as well as biological parameters t...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Whether as a bridge to a transplant or a permanent course of care, ventricular assist devices (VADs) present an essential but challenging tool for nurses, who must learn VAD operation and maintenance while also helping heart failure patients transfer from hospital to home care. Critical- and progressive-care nurses’ comfort and experience with VADs varies widely, The post Knowledge Gap at the Heart of VAD Care appeared first on Johns Hopkins Nursing Magazine.
Source: Nursing Blogs at Johns Hopkins University - Category: Nursing Authors: Tags: Cardiovascular and Chronic Conditions New CVD Diabetes heart heart disease home care Hypertension LVAD obesity research transplant ventricular assist device Source Type: blogs
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