Opsoclonus-myoclonus-encephalopathy induced by cefepime

Cefepime is an intravenous broad-spectrum cephalosporin widely used in clinical practice. Cephalosporins might produce reversible neurotoxicity due to gamma-aminobutyric acid (GABA) receptor antagonism [1], particularly when administered during renal dysfunction [2,3]. Cefepime-induced neurotoxicity is associated with myoclonus and other hyperkinetic movements, seizures and non-convulsive status epilepticus (NCSE), with concomitant mental status changes ranging from mild encephalopathy to coma [2,3].

Source: Journal of the Neurological Sciences - November 1, 2018 Category: Neurology Authors: Karlo J. Lizarraga, Deborah O. Heros, David Adams, Anthony E. Lang, Andres M. Kanner Tags: Letter to the Editor Source Type: research