Endothelin Receptor Emerges as a Potential Target of Hoxa9-mediated Leukemogenesis

In 2000, Padr ó et al. published a surprising finding -- bone marrow from patients with acute myeloid leukemia (AML) revealed evidence of increased angiogenesis. Microvessels staining positive for thrombomodulin and von Willebrand factor were observed at high density compared to normal bone marrow with evidence of endothelial sprouting and smaller lumens [1]. Unexpected for a liquid tumor, this prompted further inquiry as to whether a vascular niche may be essential to support leukemic cell growth.
Source: Leukemia Research - Category: Hematology Authors: Tags: Commentary Source Type: research