Deletion of IP 3 R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality

ConclusionsHere, we provided a novel mouse model for impaired GI motility and demonstrated that IP3R1 plays a critical role in regulating physiological function of GI tract in vivo.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research