Keytruda OK'd as First-Line Tx in Advanced, Squamous NSCLC

(MedPage Today) -- Approved in combination with carboplatin and either paclitaxel or nab-paclitaxel
Source: MedPage Today Pulmonary - Category: Respiratory Medicine Source Type: news

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ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Xiao-Jing Du, Su-Ming Pan, Shu-Zhen Lai, Xiao-Nan Xu, Mei-Ling Deng, Xiao-Hui Wang, Dun-Chen Yao, Shao-Xiong Wu
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 11 December 2018Source: The Annals of Thoracic SurgeryAuthor(s): Yoshinori Handa, Yasuhiro Tsutani, Takahiro Mimae, Takuro Tasaki, Yoshihiro Miyata, Morihito OkadaAbstractBackgroundAs segmentectomy becomes widely used for lung cancer treatment, “complex segmentectomy,” which makes several, intricate intersegmental planes, remains controversial because of procedural complexity and risk of increased complications and incurability. Questions remain regarding mortality, morbidity, surgical margin, lymph nodes dissection, and postoperative pulmonary function. We evaluated operative...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
During the production of this paper, an error appeared in the title. The title should be, “Immune Checkpoint Inhibition Combined With Intracranial Stereotactic Radiation Therapy in Non-Small Cell Lung Cancer: Is There an Increasing Rate of Radionecrosis or Not? In Regards to Schapira et al, Huppeling et al and Colaco et al.”
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Tags: Erratum Source Type: research
MicroRNA‑506‑3p reverses gefitinib resistance in non‑small cell lung cancer by targeting Yes‑associated protein 1. Mol Med Rep. 2018 Nov 29;: Authors: Zhu J, Tao L, Jin L Abstract Epidermal growth factor receptor‑tyrosine kinase inhibitors, such as gefitinib, have been found to be clinically effective in the treatment of patients with non‑small cell lung cancer (NSCLC). However, the therapeutic effect of gefitinib is often limited by the development of gefitinib resistance. MicroRNAs (miRNAs), a group of small non‑coding RNAs, have been demonstrated to be frequently dysregulated in human ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MicroRNA‑29a enhances cisplatin sensitivity in non‑small cell lung cancer through the regulation of REV3L. Mol Med Rep. 2018 Dec 04;: Authors: Chen X, Zhu H, Ye W, Cui Y, Chen M Abstract Cisplatin‑based chemotherapy may greatly enhance patient prognosis; however, chemotherapy resistance remains an obstacle to curing patients with non‑small cell lung cancer (NSCLC). The aim of the present study was to explore the microRNAs (miRs) that could regulate cisplatin sensitivity and provide a potential treatment method for cisplatin resistance in clinical. Results from the present study revealed that mi...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In this study, the expression level of FBXL3 in NSCLC tissues and cell lines was firstly examined and identified. Moreover, the relationship between FBXL3 and the overall survival rate of NSCLC patients was analyzed by Kaplan–Meier survival curve. Functionally, MTT, colony formation assay and transwell assays were performed to determine the role of FBXL3 in regulating NSCLC cell proliferation, migration and invasion. The proliferation and migration were suppressed by overexpression of FBXL3, indicating the potential tumor suppressive role of FBXL3 in NSCLC. In addition, the dual-luciferase reporter and RNA pull-down ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Valerio Nardone, Pierpaolo Pastina, Rocco Giannicola, Rita Agostino, Stefania Croci, Paolo Tini, Luigi Pirtoli, Antonio Giordano, Pierosandro Tagliaferri, Pierpaolo Correale
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Use of tumor mutation burden may help identify patients who can achieve a more pronounced survival benefit from adjuvant chemotherapy for NSCLC.Journal of Clinical Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
ConclusionsSystemic exposure to dFdCTP was higher after BAI than IV in two out of three patients.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
More News: Non-Small Cell Lung Cancer | Respiratory Medicine