Anti-Inflammatory Effects Of Variola Virus Tnf Decoy Receptor In Experimental Model Of Contact Dermatitis.

Anti-Inflammatory Effects Of Variola Virus Tnf Decoy Receptor In Experimental Model Of Contact Dermatitis. Curr Pharm Biotechnol. 2018 Oct 29;: Authors: Viazovaia EA, Gileva IP, Toporkova LB, Shchelkunov SN, Orlovskaya IA Abstract Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF). We investigated the effects of a recombinant variola (smallpox) virus TNF-decoy receptor (VARV-CrmB) in a murine model of contact dermatitis. Our results demonstrate that the VARV-CrmB protein significantly reduces the 2,4-dinitrochlorbenzene (DNCB)-induced migration of skin leukocytes during the sensitization phase and suppresses ear oedema during the elicitation phase of the contact reaction. Studies focusing on the bone marrow hematopoiesis in the contact dermatitis model revealed that the epicutaneous co-application of DNCB and VARV-CrmB protein normalized the DNCB-induced effects to control levels. As an effective TNF antagonist, the VARV-CrmB protein might be conceived as a beneficial candidate for further research and development of therapeutic approaches in the field of the inflammatory skin diseases. PMID: 30370844 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research