In vivo Human Skin Penetration of the UV Filter Ethylhexyl Triazone: Effect of Lipid Microparticle Encapsulation

Conclusion: For the cream with the nonencapsulated sunscreen agent, the percentage of the applied EHT dose diffused into the stratum corneum was 21.9 ± 4.9%, not significantly different from that of the smaller-molecular-weight OMC (22.2 ± 7.6%) and BMDBM (20.5 ± 3.7%). A marked (45.7%) and statistically significant reduction in the in vivo skin penetration of EHT was attained with the cream containing microencapsulated EHT. The decreased perc utaneous penetration provided by the LMs should favor the efficacy of EHT and limit potential toxicological risks.Skin Pharmacol Physiol 2019;32:22 –31

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Source: Skin Pharmacology and Physiology - October 31, 2018 Category: Dermatology Source Type: research