Is Controversy Over NCRT Plus Surgery Warranted in Esophageal Squamous Cell Carcinoma?

A new study adds to evidence examining whether neoadjuvant chemoradiotherapy plus surgery improves survival vs surgery alone in locally advanced ESCC.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news

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ConclusionsIn ESCC patients with pCR after trimodality treatment, IC was associated with favorable survivals. The benefits of IC might be a hypothesis generation for adjuvant treatment for patients with pCR.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
We present a 63 year-old male with mid-thoracic esophageal squamous cell carcinoma who underwent minimally invasive Ivor-Lewis Esophagectomy post neoadjuvant chemoradiotherapy. Laparoscopic dissection, gastric tube creation and mobilization was performed. Thoracoscopic esophageal dissection, subcarinal, para-esophageal and diaphragmatic lymphadenectomy were performed, followed by esophago-gastric anastomosis with double seromuscular flap reconstruction in the manner originally described by Kamikawa. The operation was completed in 618 minutes with 200ml blood loss and the patient recovered uneventfully. A morphologic sphinc...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We present a 63 year-old male with mid-thoracic esophageal squamous cell carcinoma who underwent minimally invasive Ivor-Lewis Esophagectomy post neoadjuvant chemoradiotherapy. Laparoscopic dissection, gastric tube creation and mobilization was performed. Thoracoscopic esophageal dissection, subcarinal, para-esophageal and diaphragmatic lymphadenectomy were performed, followed by esophago-gastric anastomosis with double seromuscular flap reconstruction in the manner originally described by Kamikawa. The operation was completed in 618 minutes with 200ml blood loss and the patient recovered uneventfully. A morphologic sphinc...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Objective: To determine the impact of histology on pathologic response, survival outcomes, and recurrence patterns in patients with esophageal cancer (EC) who received neoadjuvant chemoradiotherapy (CRT). Summary of Background Data: There is a paucity of data regarding comparative outcomes after neoadjuvant CRT between esophageal squamous cell carcinoma (SCC) and adenocarcinoma. Methods: Between 2002 and 2015, 895 EC patients who underwent neoadjuvant CRT followed by esophagectomy at 3 academic institutions were retrospectively reviewed, including 207 patients with SCC (23.1%) and 688 patients with adenocarcinoma (...
Source: Annals of Surgery - Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research
Condition:   Esophageal Squamous Cell Carcinoma Intervention:   Combination Product: Apatinib,Paclitaxel,Cisplatin,RT Sponsor:   Hebei Medical University Fourth Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurposeTo evaluate the accuracy of the multidetector computed tomography (MDCT) in the response evaluation of the esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT) by analyzing the thickness and post-contrast attenuation of the esophageal wall after the nCRT.MethodsContrast-enhanced (CE)-MDCT examinations in portal venous phase of one hundred patients with locally advanced ESCC who received nCRT and underwent esophageal resection and histopathology assessment of tumor regression grade (TRG) were retrospectively analyzed by measuring the maximal thickness and mean density of the esoph...
Source: Abdominal Imaging - Category: Radiology Source Type: research
ConclusionsThe effects of CRT for recurrent cancers are not influenced by neoadjuvant chemotherapy, even when using the same anticancer agent. Chemotherapy is an acceptable treatment for patients who do not receive presurgical treatment.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
AbstractBackgroundThe impact of the neoadjuvant chemoradiation-to-surgery (CRT-S) interval in patients with esophageal cancer is not clear. We aimed to determine the relationship between CRT-S interval and pathological complete response rate (pCR) and overall survival (OS).MethodsNational Cancer Data Base patients with CRT followed by surgery were studied. CRT-S interval was studied as a continuous (weeks) and categorical variable (quintiles: 15 –37, 38–45, 46–53, 54–64, and 65–90 days, withn = 1016, 1063, 1081, 1083, and 938 patients, respectively).ResultsA total of 5181 pa...
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Histological tumor type should be acknowledged in treatment choices for patients with esophageal cancer. Neoadjuvant chemoradiotherapy plus surgery should basically be advised as treatment of choice for operable esophageal adenocarcinoma patients. For patients with esophageal squamous cell carcinoma with ≥ 2 comorbidities or age ≥ 75 years, dCRT may be the preferred strategy. PMID: 30719634 [PubMed - as supplied by publisher]
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Ann Surg Oncol Source Type: research
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