Management of Acquired Hemophilia A: Review of Current Evidence

Acquired hemophilia A (AHA) is a rare acquired bleeding disorder caused by autoantibodies against autologous factor VIII (FVIII). It is a disease that most commonly affects the elderly, but it has been described in children and during the post-partum period. It is idiopathic in 50% of cases and is associated with autoimmune disease, malignancy, pregnancy, infection or certain medications in the other 50%. The diagnosis should be suspected in patients with an isolated prolonged aPPT without previous personal or familial bleeding history.

Source: Transfusion and Apheresis Science - October 30, 2018 Category: Hematology Authors: Janie Charlebois, Georges- Étienne Rivard, Jean St-Louis Source Type: research