Biperiden-Induced Delirium In A Five-Years Old Child.

We report the first case of delirium associated with use of biperiden in a preadolescent patient. CASE REPORT: A boy aged five years and weighing 20 kilograms had been diagnosed as having oppositional defiant disorder and separation anxiety disorder in the previous treatment center. Ten milligrams fluoxetine and 0.25 milligrams risperidone had been initiated. On the third day of treatment, dystonia developed and he had been administered biperiden. An hour later, he was brought to our emergency clinic due to disorganized speech and behavior. His vital signs were stable. There were no findings in blood and urine tests (Table 1). No electrolyte imbalance, liver, kidney, thyroid dysfunction have been observed. His neurologic examination was unremarkable and no abnormal findings were shown on cranial magnetic resonance imaging. No other system findings or findings pointing out to infectious diseases have been observed. One miligram physostigmine was administered with intravenous infusion. However, symptoms did not resolve and he was diagnosed as having delirium. Naranjo Adverse Drug Reaction Probability Scale score was seven indicating a "Probable" Adverse Drug Reaction. Half milligrams haloperidol was administered bid for three days and he was discharged with complete recovery. Clinicians must be aware of the risk of delirium when using non-toxic doses of biperiden in young children. PMID: 30370855 [PubMed - as supplied by publisher]
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research