The influence of total intravenous anaesthesia and isoflurane anaesthesia on plasma interleukin-6 and interleukin-10 concentrations after colorectal surgery for cancer: A randomised controlled trial

BACKGROUNDAlthough it has been demonstrated that both surgery and anaesthesia induce immune suppression, it remains unclear whether there are differences between anaesthetic techniques in inducing immune suppression in cancer patients. OBJECTIVEThe aim of this present study was to compare the effects of total intravenous anaesthesia (TIVA) and isoflurane anaesthesia on plasma concentrations of interleukins IL-6 and IL-10 in patients undergoing surgery for colorectal cancer. DESIGNA randomised, controlled, open-label study. SETTINGUniversity hospital. PATIENTSSeventy patients undergoing open colorectal surgery with tumour resection were randomised prospectively into one of two groups; 60 patients completed the study. INTERVENTIONSGroup 1 (n = 30) received TIVA and group 2 (n = 30) received isoflurane. Propofol infusion rate and inspired concentration of isoflurane were titrated to achieve bispectral index values of 40 to 55. MAIN OUTCOME MEASURESPlasma concentrations of IL-6 and IL-10 were measured preoperatively, before surgical incision and at 2 and 24 h postoperatively. The area under the curve (AUC) for IL-6 and IL-10 over 24 h and plasma interleukin concentrations at each time point were compared between the groups. RESULTSMedian (range) AUC for IL-6 was 4657 (1219 to 8427) pg h ml−1 in the TIVA group and 5349 (839 to 8126) pg h ml−1 in the isoflurane group. For IL-10, AUC was 1165 (344 to 5258) pg h ml−1 in the TIVA group and 1405 (463...
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Pharmacology Source Type: research