Bay11-7082 facilitates wound healing by antagonizing mechanical injury- and TNF- α-induced expression of MMPs in posterior cruciate ligament.

CONCLUSIONS: SCs sever as the supporting cells that aggravate the TNF-α-induced MMPs accumulation in PCLfs. Inhibition of the expression of MMPs by Bay11-7082 is a promising way to facilitate the self-healing of PCL.
PMID: 30372627 [PubMed - as supplied by publisher]

Source: Connective Tissue Research - October 30, 2018 Category: Research Tags: Connect Tissue Res Source Type: research