To investigate the affiliation of XRCC-1 Gene Arg194Trp polymorphism in alcohol and tobacco substance users and loco-regionally progressed Laryngeal squamous cell carcinoma.
Conclusion: This research investigation demonstrates the correlation of XRCC-1 polymorphic hetero genotype (CT) & mutant genotype (TT) variants as hazard factor in loco-regionally progressed LSCC. Cases with the record of alcohol intake habits, tobacco smoking and chewing habits and XRCC-1 hetero genotype (CT) variant have statistically increased the hazard of loco-regionally progressed LSCC, which demonstrate the role of gene-ecological interconnection in modifying the vulnerability of loco-regionally progressed LSCC.
PMID: 30370213 [PubMed]
Source: Cell Research - Category: Cytology Authors: Vijay Parshuram R, Kumar R, Bhatt MLB, Singh R, Parmar D, Gaur J, Kishan D, Saha M, Roopali, Katepogu P, Senthamizh P, Katiyar T Tags: J Oral Biol Craniofac Res Source Type: research
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