Antifibrotic effects of a novel pirfenidone derivative in vitro and in vivo

ConclusionPBD-617 not only inhibited TGF-β1-induced HELF proliferation, but also attenuated BLM-induced pulmonary fibrosis in rats, with efficacy to some extent higher than that of pirfenidone at the same effective dosage. PBD-617 attenuated pulmonary fibrosis effectively by suppressing activation of TGF-β1/Smad3 and p38 signaling pathways.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research