HIF-1α is critical for the activation of Notch signaling in neurogenesis during acute epilepsy

In conclusion, our results suggested that HIF-1α-Notch signaling enhanced neurogenesis in acute epilepsy and that neurogenesis during epileptogenesis was reduced once this pathway was blocked; thus, members of this pathway might be potential therapeutic targets for epilepsy.
Source: Neuroscience - Category: Neuroscience Source Type: research