Effects of lisdexamfetamine on plasma steroid concentrations compared with D-amphetamine in healthy subjects: a randomized, double-blind, placebo-controlled study

Publication date: Available online 28 October 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Petra Strajhar, Patrick Vizeli, Melanie Patt, Patrick C. Dolder, Denise V. Kratschmar, Matthias E. Liechti, Alex OdermattAbstractThe novel D-amphetamine prodrug lisdexamfetamine is applied to treat attention-deficit/hyperactivity disorder (ADHD). D-amphetamine releases dopamine and norepinephrine and stimulates the hypothalamic-pituitary-adrenal (HPA) axis, which may contribute to its reinforcing effects and risk of abuse. However, no data is currently available on the effects of lisdexamfetamine on circulating steroids. This randomized, double-blind, placebo-controlled, cross-over study evaluated the effects of equimolar doses of D-amphetamine (40 mg) and lisdexamfetamine (100 mg) and placebo on circulating steroids in 24 healthy subjects. Plasma steroid and D-amphetamine levels were determined up to 24 h. Delayed increase and peak levels of plasma D-amphetamine concentrations were observed following lisdexamfetamine treatment compared with D-amphetamine administration, however the maximal concentrations and total exposure (area under the curve [AUC]) were similar. Lisdexamfetamine and D-amphetamine significantly enhanced plasma levels of adrenocorticotropic hormone, glucocorticoids (cortisol, cortisone, corticosterone, 11-dehydrocorticosterone, and 11-deoxycortisol), androgens (dehydroepiandrosterone, dehydroepiandrosterone sulfate, and Δ4-a...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research