A Multicenter Phase 2 Study of AMG 337 in Patients With MET-Amplified Gastric/Gastroesophageal Junction/Esophageal Adenocarcinoma and Other Solid Tumors.

CONCLUSIONS: AMG 337 showed antitumor activity in MET-amplified G/GEJ/E adenocarcinoma but not in MET-amplified non-small-cell lung cancer. PMID: 30366938 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

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New England Journal of Medicine, Ahead of Print.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
New England Journal of Medicine, Ahead of Print.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
New England Journal of Medicine, Ahead of Print.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
Publication date: Available online 11 December 2019Source: The Lancet Global HealthAuthor(s): Adam Wagstaff, Sven NeelsenSummaryBackgroundThe goal of universal health coverage (UHC) requires that everyone receive needed health services, and that families who get needed services do not suffer undue financial hardship. Tracking progress towards UHC requires measurement of both these dimensions, and a way of trading them off against one another.MethodsWe measured service coverage by a weighted geometric average of four prevention indicators (antenatal care, full immunisation, and screening for breast and cervical cancers) and...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Targeted muscle reinnervation (TMR), originally developed as an experimental technique for prosthetic control, has been shown to be safe and effective for the treatment and prevention of postamputation pain. Targeted muscle reinnervation involves coaptatio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
os AC Abstract PURPOSE: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. METHODS: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, ...
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
I recently learned that a popular EM Twitter doc runs a headache clinic on the side. In conjunction with the constant threads and talks about the very real and understandable burnout in EM, I've begun thinking long-term about the implications of pursuing the specialty if I choose to do so. One area that is hard for me to get good insight and data on is on what being an EP would look like once past 50 or even 60 years of age. I am hoping for some insight from this community on this topic... M3 interested in EM: Do you plan on practicing into your late 50s or 60s?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Emergency Medicine Source Type: forums
I’ve been doing RFAs in private practice for 5 years, never any complications. Today, I slipped off the left L4 pedicle a few times, it was challenging. Adjusted the fluoro and was satisfied. No motor, lateral image did not indicate foraminal encroachment. Injected lidocaine prior to ablation. I was firmly in os and I held the probe the entire 2:30. In PACU patient complained of weakness and numbness in the L4 dermatome (FML). I was hoping it could be chalked up to the lidocaine... RFA complication
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Hi folks, Does anyone have good recommendations for favorite electives during fellowship? My program has slots for three 2-week rotations -- it is a large tertiary center with a lot of services (i.e. plenty of options). I imagine there are pearls and valuable skills to take away from nearly all available rotations. In your experience, any particularly high-yield to the practice of HPM? I'm thinking addictions, pain, .... spiritual? psych?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Hospice and Palliative Medicine Source Type: forums
Triple-negative breast cancer is difficult to treat. A new study indicates that a common chemotherapy drug improves overall survival in this tumor type -- big news in cancer treatment.Medscape Medical News
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Hematology-Oncology News Source Type: news
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