Induction of Tolerance Through Early Weaning and Oral Immunotherapy

AbstractPurpose of reviewThe increase in IgE-mediated food allergy in the world with prevalence of egg, milk, peanut, and wheat allergies presenting and coexisting as multiple food allergies in young children.Recent findingsEarlier initiation in weaning and timing of exposure of specific food allergens to an atopic infant appears to affect the trajectory and progression of acquiring tolerance in these children for specific foods. In this review, the allergen-specific strategies for increasing tolerance (desensitization) and hastening the resolution of food allergy (SU) are reviewed for treatment of food allergy.SummaryPhenotypic complexity of the individual (eczema, asthma, rhinitis), age of the child at presentation and severity of food reactions, alongside skin test size and IgE levels can determine adopting a strategy for low-dose oral immunotherapy versus conventional oral immunotherapy to complete an immunotherapy program with the least adverse events.
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research