Data Flash: RIP PubMed Health
This is not exactly a data post, but, the loss of a trusted source for clinical effectiveness research will have its effects on the dataverse. PubMed Health is being discontinued as of this coming Wednesday. As any of my colleagues can tell you, I’m taking the loss of PubMed Health hard– I loved showing it to people at various conferences, and using it myself– I found it a wonderful mid-point between MedlinePlus.gov and PubMed.gov, and it also had some great methodology resources and a glossary. All of its content will be findable in other ways though! In thinking about how to proceed in future with finding clinical effectiveness research searching, I did some exploring and gathered my findings into a poster I presented recently at the Washington State Public Health Association conference. Below, in list form, is the poster content–feel free to contact me at glusker (AT) uw.edu if you have any questions! And please send any suggestions for additions to these lists! Check Out These Ways to Find Research on Clinical Effectiveness: PubMed.gov has filters for systematic reviews and guidelines Who cares? Seek out the organizations that care about the topic (Kids? American Academy of Pediatrics!) If you or your local health sciences library have databases, check them out—for example, nursing database CINAHL has great content NLM’s “Bookshelf” is becoming a good resource for guidelines https://is.gd/NLMBookshel...
This study examined how two aesthetic features of infographics affect people's evaluation of information presented in infographic: colour and visual complexity. The findings suggested colour and visual complexity were both strong predictors of information evaluation in infographic and they should be chosen carefully in the design of infographics. PMID: 31014148 [PubMed - as supplied by publisher]
In conclusion, it was identified that silencing of miR‑193a‑3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling. The function of miR‑193a‑3p in HER2 positive breast cancer implicates its potential application in therapy. PMID: 31017268 [PubMed - in process]
MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α. Int J Mol Med. 2019 Jun;43(6):2387-2397 Authors: Hu Q, Liu F, Yan T, Wu M, Ye M, Shi G, Lv S, Zhu X Abstract The most common and aggressive type of brain cancer in adults is glioblastoma multiforme (GBM), and hypoxia is a common feature of glioblastoma. As the histological features of glioma include capillary endothelial cell proliferation, they are highly prone to invading the surrounding normal brain tissue, which is often one of the reasons for the ...
Detection of N6‑methyladenosine modification residues (Review). Int J Mol Med. 2019 Jun;43(6):2267-2278 Authors: Zhu W, Wang JZ, Xu Z, Cao M, Hu Q, Pan C, Guo M, Wei JF, Yang H Abstract Among a number of mRNA modifications, N6‑methyladenosine (m6A) modification is the most common type in eukaryotes and nuclear‑replicating viruses. m6A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m6A methyltransferases are essential during RNA modifications, the biological functions of m6A and the underlying mechanisms rem...
In conclusion, IL‑18 served a dual function in colitis by regulating the function of goblet cells. The anti‑inflammatory effects of IL‑18 were observed in the early stage of colitis‑induced inflammation, while the pro‑inflammatory effects were observed in the later stages of the disease. PMID: 31017261 [PubMed - in process]
CONCLUSIONS: Results demonstrated that 1 D displayed favourable pharmacokinetic properties for further in vivo pharmacologic evaluation, which could be facilitated by the validated LC-MS/MS method. PMID: 31017510 [PubMed - in process]
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC01461F, CommunicationBaoji Du, Weiqi Zhang, Ching-Hsuan Tung A multifunctional photosensitive and photothermal nanomedicine, AMP-Ce6-HA, was prepared by sequencially layering hard and soft functional molecules. AMP-Ce6-HA was efficiently picked up by MDA-MB-231 breast cancer cells, and then released... The content of this RSS Feed (c) The Royal Society of Chemistry
Mini-antibodies found in the blood of camels, alpacas and llamas, shrunk further to create so-called "nanobodies," may help solve a problem in the cancer field: making specific types of T-cell therapies work in solid tumors. Scientists used these nanobodies -- which resemble antibodies in human ...This is an NSF Multimedia Gallery item.
UR Medicine ’s Division of Gastroenterology and Hepatology will sponsor the 8th annual Strollin’ for the Colon 5K Walk/Run at 10 a.m. Saturday, May 11, at Geneseo’s Village Park. Strollin’ for the Colon is a non-profit organization that promotes awareness of the life-saving benefits of screening and ra ises funds for research and education.
This report aims to highlight the importance of preoperative awareness of this severe complication which, in conjunction with early recognition and immediate surgical management, may mitigate long-term adverse sequelae and improve postoperative outcomes.Resumo A s índrome compartimental aguda dos membros inferiores após cirurgia urológica na posição de litotomia é um problema clínico e médico-legal raro, mas potencialmente devastador. Reportamos o caso de um homem de 67 anos submetido a uma prostatectomia laparoscópica por câncer. A cirurgia durou 1 80 mi...
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