Nano-sized Droplets of Self-Emulsifying System for Enhancing Oral Bioavailability of Chemotherapeutic Agent VP-16 in Rats: A Nano Lipid Carrier for BCS Class IV Drugs.

CONCLUSION: The SNEDDS formulation was able to enhance the oral bioavailability of the BCS Class IV chemotherapeutic agent VP-16 by increasing the dissolution and absorption of the drug. A good in vitro in vivo correlation was found between the in vitro dissolution and in vivo absorption data of VP-16 SNEDDS preparation. Therefore, SNEDDS formulations might be a very promising approach for BCS Class IV drugs.
PMID: 30365396 [PubMed - in process]

Source: J Pharm Pharm Sci - October 28, 2018 Category: Drugs & Pharmacology Authors: Khalid N, Sarfraz M, Arafat M, Akhtar M, Löbenberg R, Ur Rehman N Tags: J Pharm Pharm Sci Source Type: research