In neonates with hypoxic ischemic encephalopathy, is therapeutic hypothermia outside of current criteria safe? A literature review

Publication date: Available online 27 October 2018Source: Journal of Neonatal NursingAuthor(s): Kirsty Dixon, Susan SmithAbstractIntroductionHypoxic Ischemic Encephalopathy (HIE) can lead to catastrophic consequences. Published trials mean that Therapeutic Hypothermia has revolutionised available treatment but infants often must meet strict criteria.ObjectivesTo review relevant research that explores using Therapeutic Hypothermia in infants with HIE, who are usually excluded from Therapeutic Hypothermia.DesignA literature review was undertaken of research that considered Therapeutic Hypothermia use outside of the standard criteria.Data sourcesMultiple databases formed part of a purposive search, alongside the open grey network, clinical trials network, Cochrane reviews, NICE guidance and National Institute for Health Research and local guidance.FindingsFive papers were reviewed, discussing Therapeutic Hypothermia after 6 h of age, infants with a syndromic diagnosis, late preterm infants (34–35weeks), post-natal collapse, surgical and cardiac infants and infants with major cranial haemorrhage. Overall the findings of the review are encouraging except for cohorts with cranial haemorrhage or syndromic diagnoses.

Source: Journal of Neonatal Nursing - October 27, 2018 Category: Perinatology & Neonatology Source Type: research