Could the environmental toxicity of diclofenac in vultures been predictable if preclinical testing methodology were applied?

Publication date: Available online 26 October 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ibrahim Zubairu Hassan, Neil Duncan, Emmanuel O. Adawaren, Vinny NaidooAbstractDiclofenac, a non-steroidal anti-inflammatory pharmaceutical agent was responsible for the death of millions of Gyps vulture’s in the Indian sub-region with the safety of the other non-steroidal anti-inflammatory drugs (NSAIDs) being questionable. With preclinical safety testing not well established for avian species unlike for mammalian and environmental toxicity, we ask the question if a preclinical model could have predicted the toxic effect of the drug. For this study, we test an Organisation for Economic Co-operation and Development (OECD) guideline 223 for assessing the acute toxic potential of pesticides in birds by exposing three avian species to the drug. Exposed Japanese quails (Coturnix japonica) and Muscovy ducks (Cairina moschata) demonstrated clinical signs and pathology similar to those previously reported in vultures viz. hyperuricemia, depression, death, visceral gout and nephrosis. However, exposed domestic pigeons (Columba livia domestica) were insensitive. Following a pharmacokinetic analysis, the drug was well absorbed and distributed in the pigeons with a half-life below 6 h. A toxicokinetic evaluation in quails showed poisoning was due to metabolic constraint, with a half-life and mean residence time above 6 h and 8 h respectively resulting ...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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Conclusions: We found that perceived stigma in health care settings was a potential barrier to good health. Prior studies have illustrated that negative health outcomes are common for patients who avoid or delay care; thus, the unfortunate conclusion is that even in a diverse, heterogeneous community, stigma persists and may negatively affect well-being. Therefore, eliminating stigma in clinical settings should be a top priority for health care providers and public health professionals seeking to improve health equity.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Would having diagnosed anxiety or depression affect chances of getting into medical school if the school finds out an applicant has such problems?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Publication date: Available online 13 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Wei Ji, Yi-Jian Zhang, Feng Zhou, Hai-qing Mao, Hui-lin Yang, Tao LiuAbstractStudy designProspective cohort study.ObjectiveThe aim of this study was to compare clinical outcomes, radiographic changes, and complications of cervical expansive open-door laminoplasty(EOLP)for cervical multilevel myelopathy, using either 3 or 5 titanium miniplates.Summary of background dataCervical EOLP is a common and effective operation for cervical myelopathy. Standard procedures utilize either 3 or 5 titanium miniplates; however, no d...
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
You're reading 7 Ways to Find Peace of Mind and Inner Calm, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. All our life, we keep on seeking the peace of mind but it is important to understand that it is not something we can buy or seek. We often get indulged in the process of seeking peace rather than attaining it. Happiness or peace is not something we can grasp, it comes from within. Yes, of course, we can try to meet people we love or buy things we like but peace is not just confined to materialistic pleasure. In...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured happiness meditation calm inner peace self improvement Source Type: blogs
ConclusionsThis underlines the importance of prevention and treatment for neuropsychiatric symptoms in ICU survivors in general, not only in specific patient groups.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
The objective of this study was to evaluate associations between marijuana use and the prevalence, severity, and rate of occurrence of tinnitus.Study designCross-sectional analysis of nationally representative data.SettingNational Health and Nutrition Examination Survey 2011–2012.Subjects and methodsStatistical analysis was performed on data collected from 2705 non-institutionalized adults aged 20–69 who underwent audiometric testing and were administered questionnaires about hearing, drug use, current health status, and medical history.ResultsThe use of marijuana at least once per month for the previous 12 m...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: 15 December 2019Source: International Journal of Pharmaceutics, Volume 572Author(s): Margarida Miranda, Alberto A.C.C. Pais, Catarina Cardoso, Carla VitorinoAbstractThe EMA draft guideline on quality and equivalence of topical products and the FDA non-binding product specific guidances release has encouraged the establishment of a regulatory background for in vitro release testing (IVRT). Herein, a novel framework applicable to the development of a discriminatory IVRT method is described, according to analytical quality by design (aQbD) principles. A commercially available diclofenac emulgel formulation w...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsThis study suggestted that the balance between masticatory muscles and the balance between muscles and skeleton collapsed in the patients with mandibu-lar laterognathism.
Source: Orthodontic Waves - Category: Dentistry Source Type: research
Publication date: Available online 13 November 2019Source: American Heart JournalAuthor(s): Geoffrey H Tofler, Marie-Christine Morel-Kopp, Monica Spinaze, Jill Dent, Christopher Ward, Sharon McKinley, Anastasia S Mihailidou, Jennifer Havyatt, Victoria Whitfield, Roger Bartrop, Judith Fethney, Holly G Prigerson, Thomas BuckleyBackgroundBereavement is associated with an increased risk of cardiovascular disease; however, no reports exist of interventions to reduce risk. In a randomized, double-blind, placebo-controlled trial of 85 recently bereaved participants, we determined whether beta-blocker (metoprolol 25 mg) and aspiri...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: January 2020Source: Molecular Immunology, Volume 117Author(s): Dejian Liu, Huijun Zheng, Yaqian Li, Peng Zhou, Hui Jin, Rui LuoAbstractJanus kinase 1 (JAK1) is a member of JAK family of non-receptor protein tyrosine kinases that plays critical roles in transducing cytokine signals via JAK-signal transducer and activator of transcription (STAT) signaling pathway. The importance of JAK1 in innate immunity has been well-studied in mammals and fish, yet in avian remains largely unknown. Here, we cloned the full-length of the duck JAK1 (duJAK1) gene for the first time. DuJAK1 encoded a protein of 1152 amino ac...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
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