Nitric oxide-mediated cytotoxic effect induced by zoledronic acid treatment on human gingival fibroblasts

Conclusions Our results suggest ROS involvement in NO overproduction, due to nNOS recruitment, both at low and high doses. In turn, NO release seems to be able to trigger the inflammatory response only when high doses are administered, thus confirming the ZA cytotoxic effect on HGFs. Clinical relevance The knowledge of ZA-mediated cytotoxicity mechanisms on HGFs allows to better understand drug pharmacological activity.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research