Cephalotaxus alkaloids from Torreya fargesii Franch and their cytotoxicities

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Meng Wang, Xian-Dong Zhang, Yue-Ling Peng, Zheng-Hui Li, Hong-Lian Ai, Ping Li, Tao Feng, Ji-Kai LiuAbstractTwo new cephalotaxus alkaloids, torreyafargesines A (1) and B (2), along with sixteen known ones (3‒18), were isolated from the leaves and barks of Torreya fargesii Franch. The structures were established on the basis of spectroscopic methods. All compounds were evaluated for their cytotoxicities against human A549 and Hela cell lines. As a result, compound 5 exhibited weak cytotoxicities against both two cell lines, while compounds 2‒4 exhibited cytotoxicities to the Hela cell line referring to that of cisplatin.Graphical abstract

Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research