Benzofurans, benzoic acid derivatives, diterpenes and pyrrolizidine alkaloids from Peruvian Senecio

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Liliana Ruiz-Vásquez, Lastenia Ruiz Mesia, Matías Reina-Artiles, M. López-Rodríguez, J. González-Platas, Cristina Giménez, Raimundo Cabrera, Azucena González-ColomaAbstractSixteen compounds incluiding four benzofurans (1–4), three benzoic acid derivatives (6–8), one eremophilane (9), four diterpenes (10–13) and four pyrrolizidine alkaloids (14–17) were isolated from Senecio subcandidus, S. klugii and S. ayapatensis from Perú. Compounds 1–4 and 6–9 have not been previously reported as natural products. Their molecular structures were determined by NMR spectroscopic analysis, comparison with published NMR data and chemical transformations. The X-ray analysis of acetylated derivative 5 and compound 7 were also performed. Their insecticidal and antifungal activities were tested.Graphical abstractSixteen compounds from endemic plants of Peru were isolated and characterized. Their insecticidal and antifungal activities were tested.
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Publication date: June 2020Source: Nonlinear Analysis: Real World Applications, Volume 53Author(s): Yu Yang, Lan Zou, Jinling Zhou, Cheng-Hsiung HsuAbstractThis paper is concerned with the dynamics of a waterborne pathogen model with spatial heterogeneity and general incidence rate. We first establish the well-posedness of this model. Then we clarify the relationship between the local basic reproduction number R̃ and the basic reproduction number R0. It could be seen that R0 plays an important role in determining the global dynamics of this model. In fact, we show that the disease-free equilibrium is globally asymptotical...
Source: Nonlinear Analysis: Real World Applications - Category: Research Source Type: research
Abstract SUMMARYSurveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-162, and OXA-244, in that order, are the most common enzymes identified among the OXA-48-like carbapenemase group. OXA-48 is associated with different Tn1999 variants on IncL plasmids and is endemic in North Africa and the Middle East. OXA-162 and OXA-244 are derivatives of OXA-48 and a...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Publication date: Available online 14 November 2019Source: Zoologischer AnzeigerAuthor(s): Frederico Falcão Salles, Jeane Marcelle C. Nascimento, Marina Monjardim, Roberta Paresque, Neusa Hamada, Eduardo DominguezAbstractA new genus and species is described based on nymphs and adults collected exclusively at the Chapada Diamantina National Park, in Brazil. The generic category of this new taxon was tested by reanalyzing a morphological dataset used to access the phylogenetic relationships of species of Ulmeritus and Ulmeritoides and by the use of molecular analysis, using two different genes. Both analysis corrobora...
Source: A Journal of Comparative Zoology - Category: Zoology Source Type: research
Publication date: Available online 14 November 2019Source: Molecular Phylogenetics and EvolutionAuthor(s): Sylvain G. Razafimandimbison, Kent Kainulainen, Bruno Senterre, Charles Morel, Catarina RydinAbstractThe granitic islands of the Seychelles harbor about 268 native angiosperm species, with 28% being endemics there. The Seychelles biota contains a mix of ancient taxa with Gondwanan origins and young taxa that arrived there via dispersals. We investigate the phylogenetic position of an enigmatic, critically endangered, Seychellean endemic of the coffee family (Rubiaceae), Psathura/Psychotria sechellarum, and assess whet...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
ConclusionGiven the presence of infection in rodents with tularemia agent in the studied area, it is crucial to elucidate the risks of rodent exposure to tularemia for physicians, health personnel and the general population.
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
CONCLUSIONS: These data contribute to a better understanding of the distribution of T. cruzi infection in the Northeastern region of Brazil. Preventive measures based on vector control should be implemented in the study ar ea in order to reduce the burden this neglected tropical disease.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
The objective of the study is to investigate the genetic diversity of P. vivax circulating in Southern Thailand by using 3 antigenic markers and 8 microsatellite markers. Dried blood spots were collected from Chumphon, Phang Nga, Ranong and, Surat Thani provinces of Thailand. By PCR, 3 distinct sizes of PvMSP3α, 2 sizes of PvMSP3β and 2 sizes of PvMSP1 F2 were detected based on the length of PCR products, respectively. PCR/RFLP analyses of these antigen genes revealed high levels of genetic diversity. The genotyping of 8 microsatellite loci showed high genetic diversity as indicated by high alleles per locus and...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
AbstractIn Xayaboury province, located in the northern region of Lao PDR, the foot and mouth disease (FMD) vaccination campaign just began in 2009. Up until now, a small number of farms have been vaccinated. When FMD outbreaks occur, it is interesting to determine the risk factors of FMD, especially in the area where vaccination rates are low. The questionnaire survey, using a case-control design at the household level, was carried out. From 59 villages with a total number of 434 households, 181 households who experienced FMD were assigned as case households, 146 households without FMD occurrence inside the outbreak villag...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
by Nur Alia Johari, Kenny Voon, Shen Yung Toh, Lokman Hakim Sulaiman, Ivan Kok Seng Yap, Patricia Kim Chooi Lim Dengue fever is endemic in Malaysia, contributing to significant economic and health burden in the country.Aedes aegypti andAe.albopictus are the main vectors of the dengue virus (DENV), which circulates in sylvatic and human transmission cycles and has been present in Malaysia for decades. The study investigated the presence and distribution of DENV in urban localities in the Klang Valley, Peninsular Malaysia. A total of 364Ae.aegypti and 1,025Ae.albopictus larvae, and 10Ae.aegypti and 42Ae.albopictus adult mos...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionsThis report confirms 12 azithromycin-resistantSalmonella Typhi strains and one Paratyphi A strain. The molecular basis of this resistance is one mutation in the AcrB protein at position 717. This is the first report demonstrating the impact of this non-synonymous mutation in conferring macrolide resistance in a clinical setting. With increasing azithromycin use, strains with R717 mutations may spread and be acquired by XDR strains. An azithromycin-resistant XDR strain would shift enteric fever treatment from outpatient departments, where patients are currently treated with oral azithromycin, to inpatient departm...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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