Isolation of 3,4-seco-27-norlanostane triterpenoids from cultivated fruiting bodies of Ganoderma orbiforme

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Wei Li, Panida Chinthanom, Pranee Rachtawee, Kamolphan Intereya, Tao Feng, Ji-Kai Liu, Masahiko IsakaAbstractFour new 3,4-seco-27-norlanostane triterpenoids, ganoboninketals E (1) and F (2), and ganoboninones G (3) and H (4), and two known derivatives (5 and 6), a new C30 lanostane, (24Z)-3β,27-dihydroxylanosta-7,9(11),24-triene (7), and twelve known lanostanes (8–19), together with three known meroterpenoids, fornicin A (20) and ganomycins B (21) and I (22), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data and chemical correlations. Biological activities of all new compounds and some selected known compounds were evaluated. Ganomycin I showed moderate activity against Gram-positive bacteria.Graphical abstract

Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research