Identification and bioactivity evaluation of ingredients from the fruits of Amomum tsaoko Crevost et Lemaire

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Hang Liu, Qingsong Yan, Deli Zou, Xialing Bu, Baojing Zhang, Xiaochi Ma, Aijing Leng, Houli Zhang, Dawei Li, Chao WangAbstractTwo new fatty acids, together with ten known compounds, were isolated from the fruits of Amomum tsaoko. Their structures were determined by extensive spectroscopic data analysis. The extracts and all the discovered compounds were tested for inhibition of Klebsiella pneumoniae (K. pneumoniae). The results showed that 95% ethanol and ethyl acetate extracts of the fruits of A. tsaoko had excellent inhibitory activities against K. pneumonia. Fatty acids 1–4, 7, 9, and 11 showed significant K. pneumoniae inhibitory activity at a concentration of 50 μg/mL (inhibition rate> 99%). The lipase inhibitory activity and DPPH radical scavenging capacity of all compounds were also evaluated. Compounds 2 and 3 exhibited better inhibitory effects than did the positive control Orlistat at a concentration of 50 μg/mL; compound 11 exhibited excellent DPPH radical scavenging activity at a concentration of 100 μg/mL.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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