Bioactive isoquinoline alkaloids from Glaucium arabicum

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Ahmed Elbermawi, Amal Sallam, Hazem A. Ghabbour, Mahmoud F. Elsebai, Mohamed F. Lahloub, Hassan-Elrady A. SaadAbstractPhytochemical investigation of the aerial parts of Glaucium arabicum Fresen. (Papaveraceae) led to the isolation of two previously undescribed isoquinoline alkaloids araglaucine A, and araglaucine B, together with seven known ones 1-[(3`,4`-dimethoxy-2`-methylcarboxy)benzoyl]-6,7-methylenedioxy isoquinoline (araglaucine C), (7R,14S)-trans-N-methylcanadinium nitrate, (R,S)-trans-N-methylstylopine, 14-hydroxy-N-methyl canadine, 14-hydroxy-N-methyl stylopine, protopine, norsanguinarine, as well as β-sitosterol, and β-sitosterol 3-O-β–d-glucoside. Their structural elucidation was based on the measurements of 1D, 2D NMR, HRESIMS, UV, IR and X-ray crystallography. The compounds were evaluated for their anti-melanogenesis activity using B16 melanoma cell lines. Compound (7R,14S)-trans-N-methylcanadinium nitrate exhibited a promising melanin synthesis inhibitory activity (∼35%) at concentration 5 μg/ml (12.01 μM) with low cytotoxicity (∼12%).Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Authors: Carpi S, Polini B, Fogli S, Podestà A, Ylösmäki E, Cerullo V, Romanini A, Nieri P Abstract Introduction: Cutaneous melanoma is the deadliest form of skin cancer, with a dramatic increase in the incidence rate worldwide over the past decade. Early detection has been shown to improve the outcome of melanoma patients. The identification of non-invasive biomarkers able to identify melanoma at an early stage remains an unmet clinical need. Circulating miRNAs (c-miRNAs), small non-coding RNAs, appear as potential ideal candidate biomarkers due to their stability in biological fluids and easy det...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
De‑O‑acylated lipooligosaccharide of E. coli B reduces the number of metastatic foci via downregulation of myeloid cell activity. Oncol Rep. 2019 Nov 08;: Authors: Mierzejewska J, Szczygieł A, Anger-Góra N, Rossowska J, Jarosz J, Wietrzyk J, Kaszowska M, Maciejewska A, Jachymek W, Niedziela T, Lukasiewicz J, Lugowski C, Boratyński J, Pajtasz-Piasecka E Abstract Lipopolysaccharides are the main surface antigens and virulence factors of gram‑negative bacteria. Removal of four ester‑bound fatty acid residues from hexaacyl lipid A of Escherichia coli lipooligosaccharide (LOS...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, knockdown of PLCB2 suppressed cell viability and promoted cell apoptosis by activating the Ras/Raf/MAPK pathway. Thus, PLCB2 may utilized as a potential therapeutic target in patients with melanoma. PMID: 31746389 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Abstract: The premises on which guidelines for the excision of primary cutaneous melanoma are based are illogical and fail to take into account peculiarities of the individual lesion. The horizontal margins of excision continue to be adjusted to the vertical thickness of the neoplasm, and recommended clinical margins do not reflect the histopathologic borders of melanoma. Micrographically controlled surgery has become accepted for acral melanomas and melanomas of the face and neck but not for melanomas on the trunk, arms, and legs, although the latter tend to be more sharply confined. Extending margins of excision for th...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Critical Review Source Type: research
Conclusions: Our present results preliminary proofed that FARP1 possibly acts as a promoter in cutaneous melanoma development and possesses the potential to be a therapeutic target in patients with cutaneous melanoma.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
Cancers, Vol. 11, Pages 1847: Targeting Angiogenesis by Blocking the ATM–SerRS–VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth Cancers doi: 10.3390/cancers11121847 Authors: Yadong Song Hongyan Lu Qiong Wang Rong Xiang Retinoic acid (RA) has been widely used to protect skin from photo damage and skin carcinomas caused by solar ultraviolet (UV) irradiation, yet the mechanism remains elusive. Here, we report that all-trans retinoic acid (tRA) can directly induce the expression of a newly identified potent anti-angiogenic factor, seryl tRNA synthetase (SerRS), whose angiostatic role ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Sudip Mukherjee, Rajesh Kotcherlakota, Shagufta Haque, Dwaipayan Bhattacharya, Jerald Mahesh Kumar, Sumana Chakravarty, Chitta Ranjan PatraAbstractEfficient delivery of chemotherapeutic drugs to tumor cells is one of the crucial issues for modern day cancer therapy. In this article, we report the synthesis of poly ethylene glycol (PEG) assisted colloidal platinum nanoparticles (PtNPs) by borohydride reduction method at room temperature. PtNPs are stable at room temperature for more than 2 years and are stable in serum and phospha...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Conditions:   Advaced Solid Tumors;   Melanoma Intervention:   Biological: AK104 Sponsors:   Akeso;   Akeso Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 20 November 2019Source: Journal of Advanced ResearchAuthor(s): Sohail Mumtaz, Pradeep Bhartiya, Neha Kaushik, Manish Adhikari, Pradeep Lamichhane, Su-Jae Lee, Nagendra Kumar Kaushik, Eun Ha ChoiAbstractOver the past few decades, microwave (MW) radiation has been widely used, and its biological effects have been extensively investigated. However, the effect of MW radiation on human skin biology is not well understood. We study the effects of pulsed high-power microwaves (HPMs) on melanoma (G361 and SK-Mel-31) and normal human dermal fibroblast (NHDF) cells. A pulsed power generator (Chundo...
Source: Journal of Advanced Research - Category: Research Source Type: research
Patients with advanced melanoma treated with a combination of ipilimumab and nivolumab are more likely to be alive five years later than patients treated with ipilimumab alone or nivolumab alone.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
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