ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.

ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.
Annu Rev Physiol. 2018 Oct 24;:
Authors: Schmid R, Evans RJ
Abstract
In the nervous system, ATP is co-stored in vesicles with classical transmitters and released in a regulated manner. ATP from the intracellular compartment can also exit the cell through hemichannels and following shear stress or membrane damage. In the past 30 years, the action of ATP as an extracellular transmitter at cell-surface receptors has evolved from somewhat of a novelty that was treated with skepticism to purinergic transmission being accepted as having widespread important functional roles mediated by ATP-gated ionotropic P2X receptors (P2XRs). This review focuses on work published in the last five years and provides an overview of ( a) structural studies, ( b) the molecular basis of channel properties and regulation of P2XRs, and ( c) the physiological and pathophysiological roles of ATP acting at defined P2XR subtypes. Expected final online publication date for the Annual Review of Physiology Volume 81 is February 10, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 30354932 [PubMed - as supplied by publisher]

Source: Annual Review of Physiology - October 24, 2018 Category: Physiology Authors: Schmid R, Evans RJ Tags: Annu Rev Physiol Source Type: research