Pharmacokinetics, Safety and Tolerability of Tylerdipine Hydrochloride, a Novel Dihydropyridine Dual L/T-type Calcium Channel Blocker, after Single and Multiple Oral Doses in Healthy Chinese Subjects

ConclusionTylerdipine hydrochloride was safe and well tolerated. The exposure (AUC) of tylerdipine over the dose range of 5 –30 mg increased in a greater than dose-proportional manner, whileCmax exhibited a rough but non-typical dose proportionality increase. A slight accumulation of tylerdipine was observed following multiple dosing.Study registrationsCTR20140862 and CTR20150660.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research