EP News: Basic and Translational
Structural and electrical remodeling play critical roles in the maintenance of atrial arrhythmias. Rommel et al (Circ Res 2018;123:550–563, PMID 29930145) sought to identify transcription factors and downstream target genes involved in atrial structural remodeling in atrial tissues from patients with permanent atrial fibrillation (AF). They identified the transcription factor ETV1 (E twenty-six variant 1) to be significantly upregulated in AF. Moreover, Etv1 expression was 5-fold higher in atria compared to ventricular tissues.
Source: Heart Rhythm - Category: Cardiology Authors: Nipavan Chiamvimonvat Tags: EP News Source Type: research