EP News: Basic and Translational

Structural and electrical remodeling play critical roles in the maintenance of atrial arrhythmias. Rommel et  al (Circ Res 2018;123:550–563, PMID 29930145) sought to identify transcription factors and downstream target genes involved in atrial structural remodeling in atrial tissues from patients with permanent atrial fibrillation (AF). They identified the transcription factor ETV1 (E twenty-six variant 1) to be significantly upregulated in AF. Moreover, Etv1 expression was 5-fold higher in atria compared to ventricular tissues.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP News Source Type: research