CO2-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death

In 2015, a multi-national randomized controlled phase IV clinical trial of adaptive servo-ventilation for the management of heart failure with central sleep apnea was halted in progress because more patients in the study group were dying than in the control group. One year later, another large clinical trial reported results on the effectiveness of continuous positive airway pressure (CPAP) in preventing sudden death and other cardiovascular events such as heart attack and stroke in patients with pre-existing vascular disease as well as obstructive sleep apnea.
Source: Cardiovascular Pathology - Category: Cardiology Authors: Source Type: research