Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

Major depressive episodes occur twice as frequent in women compared to men (Kessler et al., 2005), and women also tend to exhibit greater symptom severity and higher rates of co-morbid disorders (Marcus et al., 2008). A recent nationwide Danish cohort study of trends in depression replicated the women to men risk ratio of 2 to 1, and further replicated an even higher risk ratio for adolescent girls from expected time of puberty onset (age 12-19) with a girls to boys risk ratio of 2.7 to 1 (Skovlund et al., 2017).
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Source Type: research