Renal tubular effects of prolonged therapy with the GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes mellitus.

In conclusion, lixisenatide affects postprandial urinary excretion of several electrolytes and increases urinary pH compared to insulin glulisine in T2DM patients after 8 weeks of treatment. This is most likely explained by a drug-induced rise in blood pressure, or direct inhibitory effects on NHE3 in the proximal tubule.
PMID: 30353743 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 24, 2018 Category: Urology & Nephrology Authors: Tonneijck L, Muskiet MHA, Blijdorp CJ, Smits MM, Twisk JW, Kramer MHH, Danser AHJ, Diamant M, Joles JA, Hoorn EJ, van Raalte DH Tags: Am J Physiol Renal Physiol Source Type: research