Proton Pump Inhibitor Doesn't Reduce ICU Mortality Proton Pump Inhibitor Doesn't Reduce ICU Mortality

Giving intensive care unit (ICU) patients a proton-pump inhibitor (PPI) to prevent gastrointestinal bleeding does not seem to affect mortality, according to a European trial of nearly 3,300 adults.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Critical Care News Source Type: news

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Publication date: Available online 25 May 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Roy Lauterbach, Susana Mustafa-Mikhail, Emad Matanes, Amnon Amit, Zeev Wiener, Lior LowensteinAbstractObjectivesThe purpose of this study was to compare the learning curves, surgical outcomes and complications of multi-port access robotic-assisted laparoscopic sacrocervicopexy (MP-RSC) to single-port robotic access (SP-RSC) for vaginal apex prolapse.MethodsA retrospective study of the first 52 MP-RSC procedures compared with the first 52 SP-RSC procedures performed at one medical center. P...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 24 May 2019Source: The Lancet HaematologyAuthor(s): Margarita Kushnir, Yun Choi, Ruth Eisenberg, Devika Rao, Seda Tolu, Jackson Gao, Wenzhu Mowrey, Henny H BillettSummaryBackgroundBecause studies of direct oral anticoagulants in patients with venous thromboembolism and non-valvular atrial fibrillation have had minimal representation of morbidly obese patients (ie, body-mass index [BMI] ≥40 kg/m2), their efficacy and safety in this population are unclear. We investigated whether apixaban and rivaroxaban are as effective and safe as warfarin in morbidly obese patients.MethodsWe did a sin...
Source: The Lancet Haematology - Category: Hematology Source Type: research
This study aimed to establish the occurrence of stroke and major bleeding events in patients with nonvalvular atrial fibrillation and left atrial appendage closure with long-term follow-up and to explore the factors associated with higher long-term mortality.MethodsAnalysis of a multicenter single cohort prospectively recruited from 2009 to 2015. Thromboembolic and bleeding events were compared with those expected from CHA2DS2-VASc and HAS-BLED scores. Multivariate analysis examined variables associated with mortality during follow-up.ResultsA total of 598 patients (1093 patient-years) with a contraindication for anticoagu...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 24 May 2019Source: Annals of Medicine and SurgeryAuthor(s): Akio Kanda, Kazuo Kaneko, Osamu Obayashi, Atsuhiko Mogami, Itaru MorohashiAbstractHemophilia A is a congenital bleeding disorder caused by an X-linked hereditary pattern. Female hemophilia A carriers are usually asymptomatic, although some have far lower levels of clotting factor because more X chromosomes with the normal gene are switched off, a phenomenon referred to as "lyonization.” During a medical checkup at our hospital, a 56-year-old Japanese woman with coxalgia was also diagnosed as an obligate hemophilia A ca...
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Publication date: Available online 24 May 2019Source: Journal of EthnopharmacologyAuthor(s): Jingjing Zhou, JianXiu Zhai, Wenlin Zheng, Na Han, Zhihui Liu, Guanghui Lv, Xiaojiao Zheng, Sheng Chang, Jun YinAbstractEthnopharmacological relevanceTraditional Chinese medicine Celastrus orbiculatus Thunb (C. orbiculatus) with peel and seeds is mainly composed of flavonoids, sesquiterpenes and tripenes. According to the Traditional Chinese medicine standard of Liaoning province (2009), it has been long used to invigorate blood circulation.Aim of the studyTo identify the antithrombus fraction and components of C. orbiculatus, and ...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
BACKGROUND Topical application, oral, and IV injection of tranexamic acid (TXA) have been used to reduce surgical bleeding. OBJECTIVE To evaluate the safety and efficacy of TXA injected subcutaneously to reduce bleeding during dermatologic surgery. METHODS In this double-blinded, placebo-controlled, randomized prospective study, 131 patients were randomized to subcutaneous injection of lidocaine 2% diluted 1:1 with either saline (placebo) or TXA 100 mg/1 mL before surgery. Before the second stage or closure, size measurements of bloodstain impregnation on Telfa and surgical wound size were recorded and analyzed usi...
Source: Dermatologic Surgery - Category: Dermatology Tags: Original Article Source Type: research
Authors: Dhamane AD, Baker CL, Rajpura J, Mardekian J, Dina O, Russ C, Rosenblatt L, Lingohr-Smith M, Lin J Abstract Objective: To compare the risk of hospitalization and costs associated with major bleeding (MB) or stroke/systemic embolism (SE) among elderly patients with nonvalvular atrial fibrillation (NVAF) who initiated apixaban then switched to another oral anticoagulant (OAC) vs. those who continued with apixaban treatment. Methods: NVAF patients (≥65 years) initiating apixaban were identified from the Humana database (1/1/2013-9/30/2017) and grouped into Switcher and Continuer cohorts. For Switchers, the...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Conclusions: Trans-apical off-pump MV repair with the NeoChord system is a safe, minimally invasive procedure, with few minor complications. In well-selected candidates it provides successful treatment of degenerative MR. Results are anatomy dependent, so preoperative patient selection is crucial. PMID: 31119000 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
Conclusions: We believe that uniportal VATS is a safe, feasible, and effective technique for selected bronchiectasis patients. PMID: 31118998 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
Conclusions: Laparoscopic total mesorectal excision using the intersphincteric approach through the sacrococcygeal incision is feasible for treating patients with a contracted pelvis and super-low rectal carcinoma. PMID: 31118985 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
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