Population pharmacokinetics and simulations of imipenem in critically ill patients undergoing continuous renal replacement therapy

Imipenem is a leading antibiotic of the carbapenem family with a broad antibacterial spectrum against gram-positive, gram-negative and anaerobic bacteria [1]. It is frequently used in the treatment of critically ill patients with severe infections due to its wide spectrum of antimicrobial activity. As a β-lactam, imipenem exhibits time-dependent bactericidal activity, and the pharmacokinetic/pharmacodynamic (PK/PD) index that best correlates with its clinical efficacy is the free plasma concentration remains above MIC of the pathogens (fT>MIC) with a target of fractional time at least 40% [2].

Source: International Journal of Antimicrobial Agents - October 26, 2018 Category: Drugs & Pharmacology Authors: Sanwang Li, Feifan Xie Source Type: research